Histocompatibility

Accredited by the American Society for Histocompatibility and Immunogenetics (ASHI), the College of American Pathologists (CAP), and the United Network for Organ Sharing (UNOS), ClinImmune Labs and its expert technical staff are committed to providing the highest quality histocompatibility testing services for clinical research studies as well as clinical transplantation and transfusion programs in Colorado, across the U.S. and abroad.

Testing available for:

  • Epitope analysis as part of population studies
  • Genetic HLA Disease Association
  • Immunotherapy, including vaccine development
  • Clinical Transplantation- solid organ and hematopoietic stem cell
  • Platelet Transfusion support
  • Pharmacogenetics

Clinically Approved Assays:

  • HLA-A, B, Cw, DRB, DQ, DPB1 loci
    • Low to high resolution Class I and Class II testing for HLA-A, B, Cw, DRB1,DRB3/4/5, DQB1, DPB1
    • Low resolution testing for DQA1
    • Serological and molecular testing
  • HLA Antibody Detection
    • Panel Reactive Antibody (PRA)
      • Luminex HLA Class I, Class II, and MICA Antibody screen
      • Luminex PRA, including HLA Specificity Analysis
      • Luminex single antigen beads for Class I, Class II, and MICA antibodies
    • Titration/Quantitation studies for pre-transplant immunotherapy protocols
    • Flow crossmatching for transplant compatibility
    • Platelet support panels to assess allo-reactive HLA antibodies and HLA-A,B typing for selection of matched platelets

Services Provided:

  • Initial consultations provided for test selection, cost effectiveness, sample and turn-around time requirements
  • Customized requisitions and clear, concise reports; electronic data transfer
  • Additional test interpretation consults upon request
  • Donor search strategy support
  • Analysis of HLA allele frequency